CHMP2B anticorps (AA 163-213)

N° du produit ABIN7454583

Cet anticorps Lapin Polyclonal détecte spécifiquement CHMP2B dans WB et IHC (fp). Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour CHMP2B anticorps (AA 163-213) (ABIN7454583)

Antigène: CHMP2B (Charged Multivesicular Body Protein 2B (CHMP2B))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHMP2B est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Détail du produit anti-CHMP2B anticorps

Épitope: AA 163-213

Fonction: Rabbit anti-CHMP2B Antibody, Affinity Purified

Homologie: X. laevis,X. tropicalis,Chicken,Bovine,Orangutan

Purification: Affinity Purified

Immunogène: Between AA 163 and 213

Isotype: IgG

Information d'application

Indications d'application:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: Not recommended

WB: 1:1,000 - 1:5,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur CHMP2B

Antigène: CHMP2B (Charged Multivesicular Body Protein 2B (CHMP2B))

Autre désignation: CHMP2B

Sujet: Background: Charged multivesicular body protein 2b (CHMP2B) is a probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4 [taken from the Universal Protein Resource (UniProt) Q9UQN3].

ID gène: 25978

NCBI Accession: NP_054762

UniProt: Q9UQN3